Nurses have been involved in varying capacities in supporting people with human immunodeficiency virus (HIV) since the beginning of the HIV epidemic in the 1980s. As the epidemic has evolved from one of the greatest public health crises of the twentieth century along the chronic disease trajectory to a largely treatable and preventable chronic condition, so too has the nursing response.[1] [2] This section seeks to explore the evolving models of nursing care and roles within the HIV sector in Australia and internationally.